p-Toluenesulfonic acid → HCID 18770632, compound

HRID 479546Notes

Reaction equation

HRID 479546 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH2:7])=[O:6].[Cl:11][C:12]([Cl:16])([CH3:15])[CH:13]=O.[NH:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:17]1([CH:13]([NH:7][C:5](=[O:6])[C:4]2[CH:8]=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)[C:12]([Cl:16])([Cl:11])[CH3:15])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 680003-FluorobenzamideHCID 109754962,2-DichloropropanalHCID 178418385HCID 178418385, compound

Product 1

HCID 18770632HCID 18770632, compound

Procedure

A suspension of 3-fluorobenzamide, 2,2-dichloropropionaldehyde, benzotriazole, and p-toluenesulfonic acid was processed as described in Example 53A to provide the desired product.

Sources & evidence

ORD record
ord-e0f8043185234788acbf8065578540fe
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Reaction notes

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