p-Toluenesulfonic acid → N-[-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3-methylbenzamide

HRID 479551Notes

Reaction equation

HRID 479551 reaction equation
[C:1]1([CH3:10])[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([NH2:9])=[O:8])[CH:2]=1.[Cl:11][C:12]([Cl:16])([CH3:15])[CH:13]=O.[NH:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:17]1([CH2:13][C:12]([Cl:16])([Cl:11])[CH2:15][NH:9][C:7](=[O:8])[C:3]2[CH:4]=[CH:5][CH:6]=[C:1]([CH3:10])[CH:2]=2)[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 69253m-ToluamideHCID 109754962,2-DichloropropanalHCID 178418385HCID 178418385, compound

Product 1

HCID 70033654N-[-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3-methylbenzamide

Procedure

A suspension of m-toluamide, 2,2-dichloropropionaldehyde, benzotriazole, and p-toluenesulfonic acid was processed as described in Example 53A to provide the desired product.

Sources & evidence

ORD record
ord-db4d83a8d3ca484299aa6502c2293eaf
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Reaction notes

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