p-Toluenesulfonic acid → N-[1-(1H-1,2,3-benzotriazol-1-yl)-3,3-dimethylbutyl]-4-bromobenzamide

HRID 479560Notes

Reaction equation

HRID 479560 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.[CH3:11][C:12]([CH3:17])([CH3:16])[CH2:13][CH:14]=O.[NH:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:18]1([CH:14]([NH:8][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][C:2]([Br:1])=[CH:3][CH:4]=2)[CH2:13][C:12]([CH3:17])([CH3:16])[CH3:11])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 696834-BromobenzamideHCID 763353,3-DimethylbutanalHCID 178418385HCID 178418385, compound

Product 1

HCID 18770759N-[1-(1H-1,2,3-benzotriazol-1-yl)-3,3-dimethylbutyl]-4-bromobenzamide

Procedure

A suspension of 4-bromobenzamide, 3,3-dimethylbutanal, benzotriazole, and p-toluenesulfonic acid was processed as described in Example 53A to provide the desired product.

Sources & evidence

ORD record
ord-e8de5c5206c4421ea84e33ad5027e5d4
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Reaction notes

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