L-Leucinol → HCID 18771581, compound

HRID 479656Notes

Reaction equation

HRID 479656 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[NH2:10][C@H:11]([CH2:16][OH:17])[CH2:12][CH:13]([CH3:15])[CH3:14]>C(Cl)Cl>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][NH:10][CH:11]([CH2:12][CH:13]([CH3:15])[CH3:14])[CH2:16][OH:17])[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 111307L-LeucinolHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 18771581HCID 18771581, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2] To 6-bromo-2-pyridinecarboxaldehyde (400 mg, 2.16 mmol) was added L-leucinol (0.42 mL, 3.24 mmol) in dry CH2Cl2 (10 mL) to give 2-[(6-bromo-pyridin-2-ylmethyl)-amino]-4-methyl-pentan-1-ol as brown solid. MS m/z: 287.6 (M+H). Calc'd for Cl2H19BrN2O: 287.2.

Sources & evidence

ORD record
ord-2ed80e4067954ddb9cb4d3a623036d94
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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