4-Methylpiperidine → HCID 85809685, compound

HRID 479657Notes

Reaction equation

HRID 479657 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[CH3:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][N:14]2[CH2:15][CH2:16][CH:11]([CH3:10])[CH2:12][CH2:13]2)[N:7]=1

Participants

4

Reactant 2

HCID 693814-MethylpiperidineHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 85809685HCID 85809685, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5] To 6-bromo-2-pyridinecarboxaldehyde (400 mg, 2.15 mmol) was added 4-methylpiperidine (0.4 mL, 3.22 mmol) in dry CH2Cl2 (10 mL) to give 2-bromo-6-[(4-methyl)piperidinylmethyl]pyridine as a white solid. MS m/z: 269.4 (M+H). Calc'd for C12H17BrN2: 269.18.

Sources & evidence

ORD record
ord-d678611a49444721a7ecb28dabbc8528
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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