3-Hydroxypiperidine → HCID 18771765, compound

HRID 479660Notes

Reaction equation

HRID 479660 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[OH:10][CH:11]1[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][N:13]2[CH2:14][CH2:15][CH2:16][CH:11]([OH:10])[CH2:12]2)[N:7]=1

Participants

4

Reactant 2

HCID 232933-HydroxypiperidineHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 18771765HCID 18771765, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

8] To 6-bromo-2-pyridinecarboxaldehyde (400 mg, 2.15 mmol) was added 3-hydroxypiperidine (326 mg, 3.22 mmol) in dry CH2Cl2 (15 mL) to give 2-bromo-6-(3-hydroxypiperidinyl)methyl pyridine as pale yellow solid. MS m/z: 271.2 (M+H). Calc'd for C11H15BrN2O: 271.15.

Sources & evidence

ORD record
ord-7fcbdb4e5c1a4288acdea2e8c8a7bca7
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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