Piperidin-4-ol → HCID 18771713, compound

HRID 479661Notes

Reaction equation

HRID 479661 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][C:9]1[N:14]=[C:13]([CH:15]=O)[CH:12]=[CH:11][CH:10]=1>>[Br:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]([CH2:15][N:5]2[CH2:6][CH2:7][CH:2]([OH:1])[CH2:3][CH2:4]2)[N:14]=1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 18771713HCID 18771713, compound

Procedure

10] To 4-hydroxypiperidine (143 mg, 1.41 mmol) was added a solution of 6-bromo-2-pyridine-carboxaldehyde (200 mg, 1.08 mmol) to give 2-bromo-6-[(4-hydroxypiperidyl)methyl]-pyridine as a white -solid. MS m/z: 271.0 (M+H). Calc'd for C11H15BrN2O—271.15.

Sources & evidence

ORD record
ord-a2da5af66c0c4cdbbc337f53ba0544f2
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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