Ethyl piperidine-2-carboxylate → Ethyl 1-[(6-bromopyridin-2-yl)methyl]-piperidine-2-carboxylate

HRID 479662Notes

Reaction equation

HRID 479662 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[C:7]([O:9][CH2:10][CH3:11])=[O:8].[Br:12][C:13]1[N:18]=[C:17]([CH:19]=O)[CH:16]=[CH:15][CH:14]=1>>[Br:12][C:13]1[N:18]=[C:17]([CH2:19][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]2[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 27517Ethyl piperidine-2-carboxylateHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 18771756Ethyl 1-[(6-bromopyridin-2-yl)methyl]-piperidine-2-carboxylate

Procedure

13] Ethyl (2-piperidyl)carboxylate (0.92 mL, 5.92 mmol) was added to a solution of 6-bromo-2-pyridinecarboxaldehyde (1.0 g, 5.38 mmol) to give ethyl 1-[(6-bromopyridin-2-yl)methyl]-piperidine-2-carboxylate as a colorless oil). MS m/z: 327.1 (M+H). Calc'd for C14H1gBrN2O2—327.22.

Sources & evidence

ORD record
ord-8be46c9b314c47b385c043a37598c252
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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