proline dl-form → HCID 18771917, compound

HRID 479664Notes

Reaction equation

HRID 479664 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([OH:8])=[O:7].[Br:9][C:10]1[N:15]=[C:14]([CH:16]=O)[CH:13]=[CH:12][CH:11]=1>>[Br:9][C:10]1[N:15]=[C:14]([CH2:16][N:1]2[CH2:5][CH2:4][CH2:3][CH:2]2[C:6]([OH:8])=[O:7])[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 614proline dl-formHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 18771917HCID 18771917, compound

Procedure

15] 2-Pyrrolidine carboxylic acid (0.68 g, 5.92 mmol) was added to a solution of 6-bromo-2-pyridine-carboxaldehyde (1.0 g, 5.38 mmol) to give 1-(6-bromopyridin-2-ylmethyl)-pyrrolidine-2-carboxylic acid as a white solid. MS m/z: 285.1 (M+H). Calc'd for C11H13BrN2O2—285.14.

Sources & evidence

ORD record
ord-23b246f80c564618880f3a9345031507
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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