Hydrochloric Acid → HCID 18772048, compound

HRID 479673Notes

Reaction equation

HRID 479673 reaction equation
[CH3:1][CH:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]2[N:15]=[C:14]([NH:16][C:17]([NH:19][C:20]3[N:21]=[C:22]([C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)[S:23][CH:24]=3)=[O:18])[CH:13]=[CH:12][CH:11]=2)[CH2:3]1.[ClH:31]>>[ClH:31].[CH3:1][CH:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]2[N:15]=[C:14]([NH:16][C:17]([NH:19][C:20]3[N:21]=[C:22]([C:25]4[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=4)[S:23][CH:24]=3)=[O:18])[CH:13]=[CH:12][CH:11]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18771662HCID 18771662, compound

Product 1

HCID 18772048HCID 18772048, compound

Procedure

1-[6-(3,5-Dimethylpiperidin-1-ylmethyl)pyridin-2-yl]-3-(2-pyridin-4-ylthiazol-4-yl)urea(52 mg, 0.123 mmol, Example 64) was treated with HCl (0.08 mL, 0.135 mmol, 1 M in Et2O) to afford the title salt as a yellow solid.

Sources & evidence

ORD record
ord-2a4e14525a244614bb8ad74d064cef88
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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