Hydrochloric Acid → HCID 18771973, compound

HRID 479675Notes

Reaction equation

HRID 479675 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]3[N:20]=[C:21]([C:24]4[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=4)[S:22][CH:23]=3)=[O:17])[CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.[ClH:30]>>[ClH:30].[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]3[N:20]=[C:21]([C:24]4[CH:25]=[CH:26][N:27]=[CH:28][CH:29]=4)[S:22][CH:23]=3)=[O:17])[CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18771974HCID 18771974, compound

Product 1

HCID 18771973HCID 18771973, compound

Procedure

1-[6-(4-Methylpiperidin-1-ylmethyl)pyridin-2-yl]-3-(2-pyridin-4-yl-thiazol-4-yl)urea (70 mg, 0.171 mmol, Example 65) was treated with HCl (0.19 mL., 0.188 mmol, 1M in Et2O) to afford the title salt as a yellow solid.

Sources & evidence

ORD record
ord-bda90fa9ba974081a09b29e05b38bf94
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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