Hydrochloric Acid → HCID 18771724, compound

HRID 479679Notes

Reaction equation

HRID 479679 reaction equation
[ClH:1].[CH2:2]([N:4]([CH2:7][C:8]1[N:13]=[C:12]([NH:14][C:15]([NH:17][C:18]2[N:19]=[C:20]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[S:21][CH:22]=2)=[O:16])[CH:11]=[CH:10][CH:9]=1)[CH2:5][CH3:6])[CH3:3].CO>CCOCC>[ClH:1].[CH2:2]([N:4]([CH2:7][C:8]1[N:13]=[C:12]([NH:14][C:15]([NH:17][C:18]2[N:19]=[C:20]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[S:21][CH:22]=2)=[O:16])[CH:11]=[CH:10][CH:9]=1)[CH2:5][CH3:6])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18771725HCID 18771725, compound

Product 1

HCID 18771724HCID 18771724, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

HCl (27 μL, 0.026 mmol, 1.0 M soln in Et2O) was added to 1-(6-diethylaminomethyl-pyridin-2-yl)-3-(2-piperidin-4-yl-thiazol-4-yl)urea (11 mg, 0.026 mmol, Example 179) in a solution of MeOH (1 mL) and the resulting mixture stirred 3 h. Concentration in vacuo gave a yellow solid.

Workup

  1. concentrationConcentration in vacuo
  2. customgave a yellow solid

Sources & evidence

ORD record
ord-c42697aeb58e47599faec79287260289
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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