Hydrochloric Acid → HCID 18772098, compound

HRID 479683Notes

Reaction equation

HRID 479683 reaction equation
[ClH:1].[N:2]1([CH2:8][C:9]2[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]3[N:20]=[C:21]([C:24]4[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=4)[S:22][CH:23]=3)=[O:17])[CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.CO>CCOCC>[ClH:1].[N:2]1([CH2:8][C:9]2[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]3[N:20]=[C:21]([C:24]4[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=4)[S:22][CH:23]=3)=[O:17])[CH:12]=[CH:11][CH:10]=2)[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18771931HCID 18771931, compound

Product 1

HCID 18772098HCID 18772098, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

HCl (55 ′L, 0.05 mmol, 1.0 M in Et2O) was added to 1-[6-(morpholin-4-ylmethyl)-pyridin-2-yl]-3-[(2-pyridin-3-yl)thiazol-4-yl]urea (20 mg, 0.05 mmol, Example 180) in a solution of MeOH (1 mL) and the resulting mixture stirred 3 h. Concentration in vacuo gave a yellow solid.

Workup

  1. concentrationConcentration in vacuo
  2. customgave a yellow solid

Sources & evidence

ORD record
ord-f8d7da98ad774a16b7a4c4210cb91b94
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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