4-Fluoroaniline → (E)-4-chlorostyryl-N-4-fluorophenyl Sulfonamide

HRID 479717Notes

Reaction equation

HRID 479717 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5](/[CH:6]=[CH:7]/[S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[F:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>>[Cl:1][C:2]1[CH:13]=[CH:12][C:5](/[CH:6]=[CH:7]/[S:8]([NH:19][C:18]2[CH:20]=[CH:21][C:15]([F:14])=[CH:16][CH:17]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 5938154(E)-2-(4-chlorophenyl)ethene-1-sulfonyl chloride

Product 1

HCID 8497205(E)-4-chlorostyryl-N-4-fluorophenyl SulfonamideYield 68.5%

Procedure

A solution of (E)-4-chlorostyrylsulfonyl chloride (10 mmol) and 4-fluoroaniline (10 mmol) was subjected to General Procedure 1, part B. The title compound, melting point 105-107° C., was obtained in 68.5% yield.

Sources & evidence

ORD record
ord-585b58fcbe8f43ef903c86a6f4442ca8
Source dataset
uspto-grants-2003_11
Patent number
US06646009B2

Reaction notes

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