Sulfanilamide → (E)-styryl-N-4-sulfamylphenyl Sulfonamide

HRID 479725Notes

Reaction equation

HRID 479725 reaction equation
[CH:1](/[S:9](Cl)(=[O:11])=[O:10])=[CH:2]\[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[S:13]([NH2:23])(=[O:22])([C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1)=[O:14]>>[CH:1](/[S:9]([NH:21][C:18]1[CH:19]=[CH:20][C:15]([S:13](=[O:22])(=[O:14])[NH2:23])=[CH:16][CH:17]=1)(=[O:11])=[O:10])=[CH:2]\[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 5333SulfanilamideHCID 5369377(E)-2-phenylethene-1-sulfonyl chloride

Product 1

HCID 854239(E)-styryl-N-4-sulfamylphenyl SulfonamideYield 80%

Procedure

A solution of (E)-styrylsulfonyl chloride (10 mmol) and sulfanilamide (10 mmol) was subjected to General Procedure 1, part B. The title compound, melting point 171-173° C., was obtained in 80% yield.

Sources & evidence

ORD record
ord-6e677487ef174c3c9bf2334179cb47a1
Source dataset
uspto-grants-2003_11
Patent number
US06646009B2

Reaction notes

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