HRID479782

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NCc1ccc(-c2nc(-c3ccccc3)c(-c3ccncc3)[nH]2)cc1

HCID18771539

未命名化合物

结构：O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CCC(=O)N1O

HCID86743017

未命名化合物

PRODUCTS

生成物

结构：Cn1c(-c2ccc(CNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@@H]43)cc2)nc(-c2ccccc2)c1-c1ccncc1

HCID131720117

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To a solution containing 2-(4-Aminomethylphenyl)-4-phenyl-5-(4-pyridyl)-imidazole (1 equivalent) in DMF was added N-hydroxysuccinimide biotin (1.2 eq). Follwing normal workup and chromatography the title compound was obtained: CIMS (NH3, m/z): 523 (M++H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f338e18b179a493db67ab99d6cbda2f9
来源数据集: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06645989B2
来源说明: uspto-grants-2003_11

反应 SMILES

[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:10][C:11]([C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:13]=2)=[CH:5][CH:4]=1.[OH:26][C:27]([CH2:29][CH2:30][CH2:31][CH2:32][C@H:33]1[C@@H:41]2[C@@H:36]([NH:37][C:38]([NH:40]2)=[O:39])[CH2:35][S:34]1)=O.ON1C(=O)CC[C:44]1=O>CN(C=O)C>[C:27]([NH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]([CH3:44])[C:11]([C:20]3[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=3)=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:13]=2)=[CH:5][CH:4]=1)(=[O:26])[CH2:29][CH2:30][CH2:31][CH2:32][C@H:33]1[C@@H:41]2[C@@H:36]([NH:37][C:38]([NH:40]2)=[O:39])[CH2:35][S:34]1