反应详情

A mixture of α-bromo-4-fluoro-3-phenoxytoluene (4.86 g, 17.3 mmol) and sodium sulfite (2.39 g, 19 mmol) in 50% aqueous methanol (20 ml) is heated at reflux for 5 hours and cooled to room temperature. The resultant colorless solid is collected by filtration and washed with chilled 50% aqueous methanol and methanol to obtain 3.4 g of sodium (4-fluoro-3-phenoxyphenyl)methanesulfonate. Another 1.8 g of product is recovered from the mother liquors.

1. temperatureis heated
2. temperatureat reflux for 5 hours
3. filtrationThe resultant colorless solid is collected by filtration
4. washwashed
5. temperaturewith chilled 50% aqueous methanol and methanol