反应详情

To a solution of (1-Benzhydryl-azetidin-3-yl)-benzyl-carbamic acid tert-butyl ester (0.43 g, 1 mmol) in a mixture of methanol (18 ml) and dichloromethane (2 ml) was added ammonium formate (1.3 g, 20 mmol), and 0.15 g of 10% Pd/C. The mixture was stirred at reflux for 18 h. After cooling to room temperature, it was filtered through Celite. The solvents were evaporated, and the residue was washed with hexanes and then extracted with dichloromethane. The dichloromethane solution was evaporated to give 0.24 g of a white solid; m.p. 144-145° C.; MS (ES) m/z 263.0 (MH+).

1. temperatureat reflux for 18 h
2. filtrationit was filtered through Celite
3. customThe solvents were evaporated
4. washthe residue was washed with hexanes
5. extractionextracted with dichloromethane
6. customThe dichloromethane solution was evaporated