反应详情

To a solution of azetidin-3-yl-benzyl-carbamic acid tert-butyl ester (0.20 g, 0.76 mmol) in dichloromethane (2 ml) was added triethylamine (0.15 g, 1.5 mmol) followed by 4-fluorobenzenesulfonyl chloride (0.17 g, 0.84 mmol). The mixture was stirred at room temperature for 18 h. It was then quenched with 50% sodium carbonate solution and the volatiles were evaporated. The residue was diluted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, and evaporated. The crude material was washed with hexanes to give 0.29 g of a colorless gum; MS (ES) m/z 420.9 (MH+); HRMS (FAB) Calcd. for C21H26FN2O4S (MH+): 421.1597, Found: 421.1633.

1. customIt was then quenched with 50% sodium carbonate solution
2. customthe volatiles were evaporated
3. additionThe residue was diluted with ethyl acetate
4. washwashed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated
7. washThe crude material was washed with hexanes