反应详情

14.1 g (0.0895 mole) of 2-chloro-6-hydroxycarbonylpyridine in 133 ml of a solution of HCl in ethanol is heated for 8 hours under reflux. The solvent is evaporated off, ethyl acetate added and the mixture washed with a solution of bicarbonate. The solvent is further evaporated and the reaction product purified by flash chromatography (cyclohexane/ethyl acetate=7/3). The required product is obtained.

1. temperatureunder reflux
2. customThe solvent is evaporated off
3. additionethyl acetate added
4. washthe mixture washed with a solution of bicarbonate
5. customThe solvent is further evaporated
6. customthe reaction product purified by flash chromatography (cyclohexane/ethyl acetate=7/3)