反应详情

To a solution of (2R, 5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine (2.5 g, 11.25 mmol) in dry dichloromethane (11 ml) at 0° C. was added triethylamine (1.57 ml, 11.2 mmol) followed by chloroacetyl chloride (0.858 ml, 11.2 mmol). The resulting reaction mixture was stirred for 30 minutes. The reaction was then filtered through a pad of celite, washed with dichloromethane and the resulting filtrate was concentrated to give a yellow oil Chromatography on silica get gave the title compound (2.84 g, 86% yield).

1. customThe resulting reaction mixture
2. filtrationThe reaction was then filtered through a pad of celite
3. washwashed with dichloromethane
4. concentrationthe resulting filtrate was concentrated
5. customto give a yellow oil Chromatography on silica
6. customget