Ammonium Hydroxide → HCID 86585616, compound

HRID 480192Notes

Reaction equation

HRID 480192 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH2:16][C:17]([N:19]2[CH2:24][CH2:23][N:22]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[CH2:21][CH:20]2[CH3:33])=[O:18])=[C:6]([N:8]([C:13]#[N:14])[C:9](=[NH:12])SC)[CH:7]=1.[OH-].[NH4+:35]>CCO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH2:16][C:17]([N:19]2[CH2:24][CH2:23][N:22]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[CH2:21][C@H:20]2[CH3:33])=[O:18])=[C:6]([N:8]([C:13]#[N:14])[C:9]([NH2:35])=[NH:12])[CH:7]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 18768101HCID 18768101, compound

Product 1

HCID 86585616HCID 86585616, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 1-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-N-cyano-S-methyl-isothiourea (0.045 g, 0.092 mmol) in EtOH (1 mL) was added ammonium hydroxide (0.100 mL) and the resulting solution was shaken at 60° C. overnight. The crude reaction mixture was purified directly via radial chromatography (2 mm plate) to give the title compound (0.027 g).

Workup

  1. customThe crude reaction mixture
  2. customwas purified directly via radial chromatography (2 mm plate)

Sources & evidence

ORD record
ord-863761b98fe047c58ef3fe46421cf108
Source dataset
uspto-grants-2003_11
Patent number
US06649611B2

Reaction notes

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