HCID 20601577, compound → HCID 18768964, compound

HRID 480239Notes

Reaction equation

C([O:8][C:9](=O)[CH:10]([NH:19][C:20](=[O:38])[CH:21]([CH2:31][CH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1)[CH2:22][C:23]([N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1)=[O:24])[CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)C1C=CC=CC=1.[NH3:40].CO>>[C:9]([CH:10]([NH:19][C:20](=[O:38])[CH:21]([CH2:31][CH:32]1[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1)[CH2:22][C:23]([N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1)=[O:24])[CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)(=[O:8])[NH2:40]

Participants

Reactant 2

HCID 20601577HCID 20601577, compound

HCID 21705897Ammonia methanol

Product 1

HCID 18768964HCID 18768964, compoundYield 50%

Procedure

To 2-(2-cyclohexylmethyl-4-morpholin-4-yl-4-oxo-butyrylamino)-4-piperidin-1-yl-butyric acid benzyl ester (0.10 g, 0.18 mmol) was added NH3/MeOH (2.0 M, 10 mL) in a sealed tube and the mixture was stirred at room temperature for 3 days. The solvent was evaporated to give the title compound in 50% yield.

Workup

customThe solvent was evaporated

Sources & evidence

ORD record: ord-fdcf872366f745e6a5e6044552ac6cbe
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06649642B2

Reaction notes

Loading…