Hydrochloric Acid → HCID 178418457, compound

HRID 480411Notes

Reaction equation

HRID 480411 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:8]=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=1)[NH2:7])(=[O:3])[CH3:2].[C:14]([NH:16][C:17]([NH2:19])=[NH:18])#[N:15].[ClH:20]>O>[ClH:20].[C:1]([C:4]1[CH:5]=[C:6]([NH:7][C:14]([NH:16][C:17]([NH2:19])=[NH:18])=[NH:15])[CH:8]=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 463010Cni H1894HCID 178418324HCID 178418324, compound

Product 1

HCID 178418457HCID 178418457, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Compound No. 12. A suspension of 3,5-diacetylaniline (0.531 g) in water (8 mL) was treated with cyanoguanidine (0.285 g) and conc. HCl (0.25 mL) and heated at reflux. After 6 hr the mixture was cooled and concentrated and 0.248 g of off-white solid was filtered out and dried to give N-(3,5-diacetylphenyl)biguanide hydrochloride, mp 260-70° C (dec).

Workup

  1. temperatureheated
  2. temperatureat reflux
  3. temperatureAfter 6 hr the mixture was cooled
  4. concentrationconcentrated
  5. filtration0.248 g of off-white solid was filtered out
  6. customdried

Sources & evidence

ORD record
ord-3113c19fa55b4c5297364f8d13487d2e
Source dataset
uspto-grants-2003_11
Patent number
US06649797B2

Reaction notes

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