2-(Tri-n-butylstannyl)thiophene → HCID 178450048, compound

HRID 480459Notes

Reaction equation

HRID 480459 reaction equation
FC(F)(F)S(O[C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:17]([OH:45])([C:21]3[N:22]=[CH:23][N:24](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:25]=3)[CH:18]([CH3:20])[CH3:19])[CH:13]=2)[CH:8]=1)(=O)=O.C([Sn](CCCC)(CCCC)[C:53]1[S:54][CH:55]=[CH:56][CH:57]=1)CCC>>[NH:24]1[CH:25]=[C:21]([C:17]([C:12]2[CH:11]=[CH:10][C:9]3[C:14](=[CH:15][CH:16]=[C:7]([C:53]4[S:54][CH:55]=[CH:56][CH:57]=4)[CH:8]=3)[CH:13]=2)([OH:45])[CH:18]([CH3:20])[CH3:19])[N:22]=[CH:23]1

Participants

3

Reactant 2

HCID 27793732-(Tri-n-butylstannyl)thiopheneHCID 222850556-[1-Hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl Trifluoromethanesulfonate

Product 1

HCID 178450048HCID 178450048, compound

Procedure

In a similar manner to that described in Example 2-(i), the reaction was carried out by using 6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate (2.0 g) and 2-(tributylstannyl)thiophene (1.27 mL) to give the titled compound (1.43 g) as a colorless powder.

Sources & evidence

ORD record
ord-afdf471bf59e47b9993ef39dc88a56a1
Source dataset
uspto-grants-2003_11
Patent number
US06649643B1

Reaction notes

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