Ammonium Chloride → HCID 178465928, compound

HRID 480471Notes

Reaction equation

HRID 480471 reaction equation
[CH3:1][Mg]Cl.[CH2:4]1[C:13]2[C:12]3[CH:14]=[CH:15][C:16]([C:18]([C:20]4[N:21]=[CH:22][NH:23][CH:24]=4)=[O:19])=[CH:17][C:11]=3[CH:10]=[CH:9][C:8]=2[O:7][CH2:6][CH2:5]1.[Cl-].[NH4+]>C(OCC)C.C1COCC1>[CH2:4]1[C:13]2[C:12]3[CH:14]=[CH:15][C:16]([C:18]([C:20]4[N:21]=[CH:22][NH:23][CH:24]=4)([OH:19])[CH3:1])=[CH:17][C:11]=3[CH:10]=[CH:9][C:8]=2[O:7][CH2:6][CH2:5]1

Participants

6

Reactant 3

HCID 25517Ammonium ChlorideHCID 178418332HCID 178418332, compoundHCID 178519293HCID 178519293, compound

Product 1

HCID 178465928HCID 178465928, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of methylmagnesium chloride in diethyl ether (3M; 3 mL) was added to a solution of (2,3-dihydro-1H-benzo[f]chromen-8-yl)(1H-imidazol-4-yl)ketone (0.50 g) in THF (20 ml) at 0° C. The mixture was stirred at room temperature for 3 h. Aqueous ammonium chloride solution was added to the mixture and extracted with ethyl acetate. The extract was dried and concentrated. The residue was washed with ethyl acetate to give the titled compound (0.49 g) as a colorless solid.

Workup

  1. extractionextracted with ethyl acetate
  2. customThe extract was dried
  3. concentrationconcentrated
  4. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-fcd58d94c0934bc8ad20c369a7db5a38
Source dataset
uspto-grants-2003_11
Patent number
US06649643B1

Reaction notes

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