反应详情

温度

60 °C

A mixture of N-cyclopropyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthamide (16.0 g) and pyridinium chloride (6.46 g) in methanol (84 mL) was heated at 60° C. for 3 h. The mixture was neutralized with sodium bicarbonate solution. The solvent was evaporated and the residue was dissolved in ethanol and insoluble material was filtered off. The filtrate was concentrated and purified by column chromatography (eluent; CHCl3: 8% methanolic ammonia=19:1→9:1) to give the titled compound (8.9 g) as a colorless powder.

1. customThe solvent was evaporated
2. dissolutionthe residue was dissolved in ethanol
3. filtrationinsoluble material was filtered off
4. concentrationThe filtrate was concentrated
5. custompurified by column chromatography (eluent; CHCl3: 8% methanolic ammonia=19:1→9:1)