Cycloheptylamine → HCID 178450073, compound

HRID 480490Notes

Reaction equation

HRID 480490 reaction equation
[OH:1][C:2]([C:30]1[CH:31]=[C:32]2[C:37](=[CH:38][CH:39]=1)[CH:36]=[C:35]([C:40]([O:42]C)=O)[CH:34]=[CH:33]2)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].OC(C1C=C2C(=CC=1)C=C(C(O)=O)C=C2)(C1N=C[N:52]([C:54]([C:67]2[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=2)(C2C=CC=CC=2)C2C=CC=CC=2)C=1)C(C)C.C1(N)CCCCCC1>>[CH:54]1([NH:52][C:40]([C:35]2[CH:34]=[CH:33][C:32]3[C:37](=[CH:38][CH:39]=[C:30]([C:2]([OH:1])([C:6]4[N:7]=[CH:8][NH:9][CH:10]=4)[CH:3]([CH3:5])[CH3:4])[CH:31]=3)[CH:36]=2)=[O:42])[CH2:67][CH2:72][CH2:71][CH2:70][CH2:69][CH2:68]1

Participants

4

Reactant 3

HCID 2899CycloheptylamineHCID 187691016-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoic acidHCID 22285069methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoate

Product 1

HCID 178450073HCID 178450073, compound

Procedure

In a manner to that described in Example 9-(i), methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoate (490 mg) was converted to 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoic acid, which was reacted with cycloheptylamine (0.20 mL) in a similar manner as described in Example 24-(i) to give the titled compound (560 mg) as a colorless powder.

Sources & evidence

ORD record
ord-db255ca696c74fb98d2bdcbc16cd43d9
Source dataset
uspto-grants-2003_11
Patent number
US06649643B1

Reaction notes

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