Dimethylamine, hydrochloride → HCID 178450297, compound

HRID 480493Notes

Reaction equation

HRID 480493 reaction equation
[OH:1][C:2]([C:30]1[CH:31]=C2C(=C[CH:39]=1)C=C(C(OC)=O)C=C2)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)C(C)C.OC([C:73]1[CH:74]=[C:75]2[C:80](=[CH:81][CH:82]=1)[CH:79]=[C:78]([C:83]([OH:85])=O)[CH:77]=[CH:76]2)(C1N=CN(C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)C=1)C(C)C.Cl.[CH3:87][NH:88][CH3:89]>>[OH:1][C:2]([C:79]1[C:80]2[C:75](=[CH:74][CH:73]=[CH:82][CH:81]=2)[CH:76]=[CH:77][C:78]=1[C:83]([N:88]([CH3:89])[CH3:87])=[O:85])([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:30]([CH3:39])[CH3:31]

Participants

4

Reactant 3

HCID 10473Dimethylamine, hydrochlorideHCID 187691016-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoic acidHCID 22285069methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoate

Product 1

HCID 178450297HCID 178450297, compound

Procedure

In a manner to that described in Example 9-(i), methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoate (2.0 g) was converted to 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoic acid, which was reacted with dimethylamine hydrochloride (346 mg) in a similar manner as described in Example 24-(i) to give the titled compound (1.87 g) as a colorless powder.

Sources & evidence

ORD record
ord-f625d3dc88a8443fad5bdafebfb86149
Source dataset
uspto-grants-2003_11
Patent number
US06649643B1

Reaction notes

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