N-methyl-6-((trityl-1H-imidazol-4-yl)carbonyl)-2-naphthamide → HCID 178485271, compound

HRID 480504Notes

Reaction equation

HRID 480504 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([C:17]3[N:18]=[CH:19][N:20](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:21]=3)=[O:16])[CH:11]=2)[CH:6]=1)=[O:4].[CH:41]1([Mg]Br)[CH2:43][CH2:42]1>C1COCC1>[CH:41]1([C:15]([OH:16])([C:17]2[N:18]=[CH:19][NH:20][CH:21]=2)[C:10]2[CH:11]=[C:12]3[C:7](=[CH:8][CH:9]=2)[CH:6]=[C:5]([C:3]([NH:2][CH3:1])=[O:4])[CH:14]=[CH:13]3)[CH2:43][CH2:42]1

Participants

4

Reactant 2

HCID 18769037N-methyl-6-((trityl-1H-imidazol-4-yl)carbonyl)-2-naphthamideHCID 178418630HCID 178418630, compound

Product 1

HCID 178485271HCID 178485271, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The similar reaction as described in Example 50-(i) was carried out by using N-methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide (500 mg) and cyclopropyl-magnesium bromide in THF (1M; 4 mL) to give the titled compound (332 mg) as colorless powder.

Workup

  1. customThe similar reaction

Sources & evidence

ORD record
ord-b9d88d8b091e45b496c93d7121f3a7e0
Source dataset
uspto-grants-2003_11
Patent number
US06649643B1

Reaction notes

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