Fumaric Acid → HCID 178458198, compound

HRID 480507Notes

Reaction equation

HRID 480507 reaction equation
[OH:1][C@@:2]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([C:20]([NH:22][CH3:23])=[O:21])[CH:14]=[CH:13]2)([C:5]1[N:6]=[CH:7][NH:8][CH:9]=1)[CH2:3][CH3:4].[C:24]([OH:31])(=[O:30])/[CH:25]=[CH:26]/[C:27]([OH:29])=[O:28]>CCO>[C:24]([OH:31])(=[O:30])/[CH:25]=[CH:26]/[C:27]([OH:29])=[O:28].[OH:1][C@@:2]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([C:20]([NH:22][CH3:23])=[O:21])[CH:14]=[CH:13]2)([C:5]1[N:6]=[CH:7][NH:8][CH:9]=1)[CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 178458196HCID 178458196, compound

Product 1

HCID 178458198HCID 178458198, compoundYield 88.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a heated (70° C.) solution of (S)-(−)-6-[1-hydroxy-1-(1H-imidazol-4-yl)propyl]-N-methyl-2-naphthamide (6.20 g) was added a hot solution of fumaric acid (2.20 g) in EtOH (30 mL), and the mixture was stand at room temperature. The obtained crystals were filtered, washed with EtOH, and dried in vacuo to give the title compound (7.15 g) as a colorless powder.

Workup

  1. customat room temperature
  2. filtrationThe obtained crystals were filtered
  3. washwashed with EtOH
  4. customdried in vacuo

Sources & evidence

ORD record
ord-dbf83e93ba0a4a4cb62370b0ff8dc66a
Source dataset
uspto-grants-2003_11
Patent number
US06649643B1

Reaction notes

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