Hydrochloric Acid → HCID 18766473, compound

HRID 480700Notes

Reaction equation

HRID 480700 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][CH:21]=1)[O:8][C:9]([CH3:18])([CH3:17])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[O:4].[OH-].[Na+].Cl>CO>[C:13]([O:12][C:10]([C:9]([CH3:18])([O:8][C:7]1[CH:6]=[C:5]([CH:21]=[CH:20][CH:19]=1)[C:3]([OH:4])=[O:2])[CH3:17])=[O:11])([CH3:14])([CH3:15])[CH3:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18766428HCID 18766428, compound

Product 1

HCID 18766473HCID 18766473, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

tert-Butyl 2-(3-methoxycarbonylphenoxy)-2-methylpropionate (17.03 g, 57.80 mmol) was dissolved in methanol (80 mL). Subsequently, an aqueous 3M sodium hydroxide solution (40 mL) was added thereto, and the mixture was stirred for three hours at room temperature. After completion of reaction, the mixture was acidified with hydrochloric acid under ice-cooling, to thereby precipitate colorless crystals. The crystals were subjected to filtration, thorough washing with water, and drying under reduced pressure, whereby colorless crystals were obtained (14.92 g, 53.22 mmol, 92.0%).

Workup

  1. customAfter completion of reaction
  2. temperaturecooling
  3. customto thereby precipitate colorless crystals
  4. filtrationThe crystals were subjected to filtration
  5. washthorough washing with water
  6. customdrying under reduced pressure, whereby colorless crystals
  7. customwere obtained (14.92 g, 53.22 mmol, 92.0%)

Sources & evidence

ORD record
ord-c6c35ae5caef477c99890007f6be4f05
Source dataset
uspto-grants-2003_11
Patent number
US06653334B1

Reaction notes

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