Chlorosulfonic acid → HCID 18766653, compound

HRID 480927Notes

Reaction equation

HRID 480927 reaction equation
[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[C:5]([O:10][CH3:11])[CH:4]=1)#[N:2].Cl[S:13]([OH:16])(=[O:15])=[O:14]>C(Cl)(Cl)Cl>[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH:7][S:13](=[O:15])(=[O:14])[OH:16])=[C:5]([O:10][CH3:11])[CH:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 118159314-Amino-3-methoxybenzonitrile

Product 1

HCID 18766653HCID 18766653, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 4-cyano-2-methoxyaniline (1 mmol) in chloroform (1 mL) at −78° C. is added chlorosulfonic acid. Upon reaction completion, the crude material is concentrated and may be purified by recrystalization to give N-(4-cyano-2-methoxyphenyl)-sulfamic acid.

Workup

  1. customUpon reaction completion
  2. concentrationthe crude material is concentrated
  3. custommay be purified by recrystalization

Sources & evidence

ORD record
ord-a8a0e5620d3d4631960543ac88b34b4c
Source dataset
uspto-grants-2003_11
Patent number
US06653347B2

Reaction notes

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