HCID 131724221, compound → HCID 18765895, compound

HRID 481016Notes

Reaction equation

HRID 481016 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2/[CH:16]=[CH:17]/[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[Pd]>[N:1]1([CH2:6][CH2:7][O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 131724221HCID 131724221, compound

Product 1

HCID 18765895HCID 18765895, compoundYield 97.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl (2E)-3-(2-{[2-(1-pyrrolidinyl)ethoxy]methyl}phenyl)-2-propenoate (8.27 g, 27.3 mmol) and 5% Pd/C (800 mg) in ethanol (50 ml) was hydrogenated under a hydrogen balloon for 3 h The reaction mixture was filtered through a pad of celite and the resulting Pd/C on the celite pad was washed with ethanol. The filtrate was evaporated in vacuo to afford the titled compound (8.10 g, 97.2%) as a yellow oil.

Workup

  1. customfor 3 h
  2. filtrationwas filtered through a pad of celite
  3. washthe resulting Pd/C on the celite pad was washed with ethanol
  4. customThe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-df59ac7e0965406b915a0e521d4e9f85
Source dataset
uspto-grants-2003_11
Patent number
US06653313B2

Reaction notes

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