Water → 1-Chloro-3-(diethylamino)-2-propanol

HRID 481040Notes

Reaction equation

[Cl:1][CH2:2][CH:3]1[CH2:5][O:4]1.O.[CH2:7]([NH:9][CH2:10][CH3:11])[CH3:8]>>[Cl:1][CH2:2][CH:3]([OH:4])[CH2:5][N:9]([CH2:10][CH3:11])[CH2:7][CH3:8]

Participants

Reactant 3

HCID 962Water

HCID 7835Epichlorohydrin

HCID 8021Diethylamine

Product 1

HCID 52988591-Chloro-3-(diethylamino)-2-propanol

Conditions

Temperature: 31.5 °C

Procedure

To 2-chloromethyloxirane (95 g, 1.03 mole) was added a mixture of water (3.08 g, 0.17 mole) and diethylamine (106.2 mL, 1.03 mole) at 30° C. The reaction mixture was then stirred at 28-35° C. for 6 hour and cooled to 20-25° C. to give 1-chloro-3-diethylamino-propan-2-ol.

Workup

temperaturecooled to 20-25° C.

Sources & evidence

ORD record: ord-da434449c5964325a3b53bc68ed9fc92
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06653308B2

Reaction notes

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