Ammonium Hydroxide → 1-Amino-3-(diethylamino)propan-2-ol
Reaction equation
[OH-].[NH4+:2].[CH2:3]([N:7]([CH2:10][CH3:11])[CH2:8][CH3:9])[CH:4]1[O:6][CH2:5]1>>[NH2:2][CH2:5][CH:4]([OH:6])[CH2:3][N:7]([CH2:10][CH3:11])[CH2:8][CH3:9]Participants
3
Conditions
- Temperature
- 2.5 °C
Procedure
To the ice-cold solution of ammonium hydroxide (25 mL, 159 mmole) of 25% (w/w) was added glycidyldiethylamine dropwise (3.2 g, 24.8 mmol) over 10 minutes. The reaction mixture was stirred at 0-5° C. for 1 hour and then room temperature for 14 hours. The resulting reaction mixture was evaporated and distilled (84-90° C. at 500-600 mT) to yield 1-amino-3-diethylamino-propan-2-ol (3.3 g, 92%). MS m/z 147 ([M+1]+.).
Workup
- waitroom temperature for 14 hours
- customThe resulting reaction mixture
- customwas evaporated
- distillationdistilled (84-90° C. at 500-600 mT)
Sources & evidence
- ORD record
- ord-a346f16600a04d03b887a8dd38d257a4
- Source dataset
- uspto-grants-2003_11
- Patent number
- US06653308B2
Reaction notes
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