HCID 131724224, compound → HCID 69973074, compound

HRID 481259Notes

Reaction equation

HRID 481259 reaction equation
[CH3:1][C@:2]12[C@H:60]3[CH2:61][C@H:58]([C:59]3([CH3:63])[CH3:62])[CH2:57][C@H:3]1[O:4][B:5]([C@@H:7]([NH:10][C:11]([C@H:13]1[N:17]3[C:18](=[O:44])[C:19]([N:22](C(OCC4C=CC=CC=4)=O)[CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=4)=[CH:20][N:21]=[C:16]3[C@@:15]([CH2:46][C:47]([O:49]CC3C=CC=CC=3)=[O:48])([CH3:45])[CH2:14]1)=[O:12])[CH2:8][CH3:9])[O:6]2>CO.[Pd]>[CH3:1][C@:2]12[C@H:60]3[CH2:61][C@H:58]([C:59]3([CH3:62])[CH3:63])[CH2:57][C@H:3]1[O:4][B:5]([C@@H:7]([NH:10][C:11]([C@H:13]1[N:17]3[C:18](=[O:44])[C:19]([NH:22][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:32])([F:31])[F:33])[CH:25]=4)=[CH:20][N:21]=[C:16]3[C@@:15]([CH2:46][C:47]([OH:49])=[O:48])([CH3:45])[CH2:14]1)=[O:12])[CH2:8][CH3:9])[O:6]2

Participants

4

Reactant 1

HCID 131724224HCID 131724224, compound

Product 1

HCID 69973074HCID 69973074, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 117f (293 mg, 0.337 mmol) in 5 mL MeOH, was added 29 mg 10% Pd-C. The mixture was evacuated and flushed with H2 (3×), then was stirred under an atmosphere of H2 for 45 min. The mixture was filtered and concentrated in vacuo to afford 217 mg (100%) of 117g as a colorless glass. MS(ESI) 645.4 (M+H+)

Workup

  1. customThe mixture was evacuated
  2. customflushed with H2 (3×)
  3. filtrationThe mixture was filtered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-24cd192f84c94caeaa45d71a6e52230c
Source dataset
uspto-grants-2003_11
Patent number
US06653295B2

Reaction notes

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