Triethylamine → HCID 19066135, compound

HRID 481299Notes

Reaction equation

HRID 481299 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12]C)=[O:11])=[CH:5][CH:4]=1.C(O)(=O)C.[N:18]1([C:24]2[CH:34]=[CH:33][CH:32]=[CH:31][C:25]=2[C:26]([O:28]CC)=[O:27])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.C(N(CC)CC)C>O1CCOCC1>[C:26]([C:25]1[CH:31]=[CH:32][CH:33]=[CH:34][C:24]=1[N:18]1[CH2:23][CH2:22][N:21]([CH2:2][C:3]2[CH:4]=[CH:5][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:7][CH:8]=2)[CH2:20][CH2:19]1)([OH:28])=[O:27]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 11770640Methyl 2-(4-(bromomethyl)phenyl)acetateHCID 67585122HCID 67585122, compound

Product 1

HCID 19066135HCID 19066135, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using 2.4 g of methyl 4-bromomethylphenylacetate, 2.9 g of ethyl 2-piperazinylbenzoate acetate, 3 ml of triethylamine, and 80 ml of dioxane, the reaction procedure of Example 2 was otherwise repeated and the reaction product was recrystallized from ethanol-water to provide 2.0 g of the title compound melting at 179° C.-181° C.

Workup

  1. customthe reaction procedure of Example 2
  2. customthe reaction product was recrystallized from ethanol-water

Sources & evidence

ORD record
ord-cdbb4796068b447289ce69989cbee4ad
Source dataset
uspto-grants-1998_08
Patent number
US05789409

Reaction notes

Loading…