Nitrogen mustard hydrochloride → 177489-11-1

HRID 481350Notes

Reaction equation

HRID 481350 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=2)[CH2:4][CH2:3]1.[Cl:15]C1C=CC(O)=CC=1N.Cl.ClCCN(CCCl)C.C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[Cl:15][C:13]1[CH:12]=[CH:11][C:10]([OH:14])=[CH:9][C:8]=1[N:5]1[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]1

Participants

6

Reactant 4

HCID 5935Nitrogen mustard hydrochlorideHCID 10340Sodium CarbonateHCID 50700783-Amino-4-chlorophenolHCID 110114553-(4-Methylpiperazin-1-yl)phenol

Product 1

HCID 15391879177489-11-1

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

4-chloro-3-(4-methylpiperazin-1-yl)phenol Compound 14B is prepared according to the same procedure as 13A, using the following reactants: 14A (1.1 g, 10.1 mmol); 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (1.96 g, 10.1 mmol); sodium carbonate (535 mg, 5.05 mmol) in 1-butanol (40 ml).

Sources & evidence

ORD record
ord-524a22974be9469687f019d4efcb2b95
Source dataset
uspto-grants-1998_08
Patent number
US05789412

Reaction notes

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