HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrogen mustard hydrochloride → 4-Chloro-3-(4-methylpiperazin-1-YL)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrogen mustard hydrochloride | HCID 5935 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Amino-4-chlorophenol | HCID 5070078 | — |
| Reactant | 3-(4-Methylpiperazin-1-yl)phenol | HCID 11011455 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 4-Chloro-3-(4-methylpiperazin-1-YL)phenol | HCID 15391879 | — |
Reaction Steps
4-chloro-3-(4-methylpiperazin-1-yl)phenol Compound 14B is prepared according to the same procedure as 13A, using the following reactants: 14A (1.1 g, 10.1 mmol); 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (1.96 g, 10.1 mmol); sodium carbonate (535 mg, 5.05 mmol) in 1-butanol (40 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789412 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-524a22974be9469687f019d4efcb2b95 |
| Source note | uspto-grants-1998_08 |