8-Amino-2-naphthalenol → 8-(4-Methylpiperazin-1-yl)naphthalen-2-ol

HRID 481351Notes

Reaction equation

HRID 481351 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10](O)[CH:11]=[CH:12][CH:13]=2)[CH2:4][CH2:3]1.NC1C=CC=C2C=1[CH:24]=[C:23]([OH:26])[CH:22]=[CH:21]2.C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:9]=2[CH:24]=[C:23]([OH:26])[CH:22]=[CH:21]3)[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 83588-Amino-2-naphthalenolHCID 10340Sodium CarbonateHCID 110114553-(4-Methylpiperazin-1-yl)phenol

Product 1

HCID 108002178-(4-Methylpiperazin-1-yl)naphthalen-2-olYield 48%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Compound 16A is prepared according to the same procedure as 13A, using the following reactants: 8-aminonaphthalen-2-ol (1.6 g, 10 mmol) 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (2 g, 10.4 mmol), sodium carbonate (0.54 g, 5 mmol), 1-butanol (20 ml).

Sources & evidence

ORD record
ord-b9d3068031634f1f82632db11da505a4
Source dataset
uspto-grants-1998_08
Patent number
US05789412

Reaction notes

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