HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1-Chlorocarbonyl-4-(2,3-dimethylphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 1-(2,3-Xylyl)piperazine | HCID 70541 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | HCID 19066233 | HCID 19066233 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Chlorocarbonyl-4-(2,3-dimethylphenyl)piperazine | HCID 15408861 | 78% |
Reaction Steps
1-chlorocarbonyl-4-(2,3-dimethylphenyl)piperazine Compound 40A is prepared according to the procedure described for compound 15A, using the following reactants: 1-(2,3-dimethylphenyl)piperazine (3.94 g, 20.7 mmol); triphosgene (2.05 g, 6.9 mmol); pyridine (1.68 ml, 21 mmol); dichloromethane (150 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789412 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-0d6f83bbed83498bbf90b7f2c4ebcd36 |
| Source note | uspto-grants-1998_08 |