Pyridine → 1-Chlorocarbonyl-4-(2,3-dimethylphenyl)piperazine

HRID 481361Notes

Reaction equation

HRID 481361 reaction equation
[Cl:1][C:2]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])[CH2:6][CH2:5]1)=[O:3].[CH3:17]C1C(C)=CC=CC=1N1CCNCC1.ClC(Cl)(OC(=O)OC(Cl)(Cl)Cl)Cl.N1C=CC=CC=1>ClCCl>[Cl:1][C:2]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:17])[C:11]=2[CH3:16])[CH2:6][CH2:5]1)=[O:3]

Participants

6

Reactant 4

HCID 1049PyridineHCID 705411-(2,3-Xylyl)piperazineHCID 94429TriphosgeneHCID 19066233HCID 19066233, compound

Product 1

HCID 154088611-Chlorocarbonyl-4-(2,3-dimethylphenyl)piperazineYield 78%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-chlorocarbonyl-4-(2,3-dimethylphenyl)piperazine Compound 40A is prepared according to the procedure described for compound 15A, using the following reactants: 1-(2,3-dimethylphenyl)piperazine (3.94 g, 20.7 mmol); triphosgene (2.05 g, 6.9 mmol); pyridine (1.68 ml, 21 mmol); dichloromethane (150 ml).

Sources & evidence

ORD record
ord-0d6f83bbed83498bbf90b7f2c4ebcd36
Source dataset
uspto-grants-1998_08
Patent number
US05789412

Reaction notes

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