Hydrazine hydrate (1:1) → HCID 19066236, compound

HRID 481370Notes

Reaction equation

HRID 481370 reaction equation
[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]2)=[CH:7][CH:6]=[CH:5][C:4]=1[N+:16]([O-])=O.O.NN>[Ni].C(O)C>[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:10][CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]2)=[CH:7][CH:6]=[CH:5][C:4]=1[NH2:16]

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19066164HCID 19066164, compound

Product 1

HCID 19066236HCID 19066236, compoundYield 67%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

Compound 54A is prepared according to the procedure described for compound 33C, using the following reactants: 2-methoxy-3-(4-methylpiperazin-1-yl)-1-nitrobenzene (3.6 g); hydrazine hydrate (4 ml); ethanol (50 ml); Raney nickel (one spatula-ful). The crude product is purified by flash chromatography with a mixture (90/9/1) of dichloromethane/methanol/aqueous ammonia).

Workup

  1. customThe crude product is purified by flash chromatography with a mixture (90/9/1) of dichloromethane/methanol/aqueous ammonia)

Sources & evidence

ORD record
ord-7eeb2e54de9e45e78c4b8b4c9f3386fa
Source dataset
uspto-grants-1998_08
Patent number
US05789412

Reaction notes

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