5,7-Dimethyl-2-propyl-1H-imidazo[4,5-b]pyridine → 1-[5-(5,7-Dimethyl-2-propylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]cyclopent-3-ene carboxylic acid ethyl ester

HRID 481392Notes

Reaction equation

HRID 481392 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:11]2[S:12][C:13]([CH2:16]Cl)=[CH:14][CH:15]=2)[CH2:10][CH:9]=[CH:8][CH2:7]1)=[O:5])[CH3:2].[CH2:18]([C:21]1[NH:22][C:23]2[C:24]([N:31]=1)=[N:25][C:26]([CH3:30])=[CH:27][C:28]=2[CH3:29])[CH2:19][CH3:20]>>[CH2:1]([O:3][C:4]([C:6]1([C:11]2[S:12][C:13]([CH2:16][N:31]3[C:24]4=[N:25][C:26]([CH3:30])=[CH:27][C:28]([CH3:29])=[C:23]4[N:22]=[C:21]3[CH2:18][CH2:19][CH3:20])=[CH:14][CH:15]=2)[CH2:10][CH:9]=[CH:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 150761425,7-Dimethyl-2-propyl-1H-imidazo[4,5-b]pyridineHCID 545331371-(5-Chloromethylthiophen-2-yl)-cyclopent-3-ene carboxylic acid ethyl ester

Product 1

HCID 700866051-[5-(5,7-Dimethyl-2-propylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]cyclopent-3-ene carboxylic acid ethyl ester

Procedure

Alkylation was performed on (5) as described in Example 1, Step 5, above, using 2-propyl-5,7-dimethylimidazo[4,5-b]pyridine (10) to yield the title compound (9).

Sources & evidence

ORD record
ord-3002a2b489934cfbb4065b5dd036de0f
Source dataset
uspto-grants-1998_08
Patent number
US05789415

Reaction notes

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