2,6-Dimethyl-8-ethyl-1-deazapurine → 2-[5-(2-Ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]indan-2-carboxylic acid ethyl ester

HRID 481395Notes

Reaction equation

HRID 481395 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:15]2[S:16][C:17]([CH2:20]Cl)=[CH:18][CH:19]=2)[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5])[CH3:2].[CH2:22]([C:24]1[NH:25][C:26]2[C:27]([N:34]=1)=[N:28][C:29]([CH3:33])=[CH:30][C:31]=2[CH3:32])[CH3:23]>>[CH2:1]([O:3][C:4]([C:6]1([C:15]2[S:16][C:17]([CH2:20][N:34]3[C:27]4=[N:28][C:29]([CH3:33])=[CH:30][C:31]([CH3:32])=[C:26]4[N:25]=[C:24]3[CH2:22][CH3:23])=[CH:18][CH:19]=2)[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 98153742,6-Dimethyl-8-ethyl-1-deazapurineHCID 570789242-(5-Chloromethylthiophen-2-yl)-indan-2-carboxylic acid ethyl ester2×

Product 1

HCID 867529582-[5-(2-Ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]indan-2-carboxylic acid ethyl ester

Procedure

The product of Step 4, above (26), was alkylated as described in Example 1, Step 5 using 2-ethyl-5,7-dimethylimidazo[4,5-b]pyridine (7) to yield the title compound (27).

Sources & evidence

ORD record
ord-c9f7bc7332e0458bbe46181f76d86883
Source dataset
uspto-grants-1998_08
Patent number
US05789415

Reaction notes

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