反应详情

温度

65 °C

A mixture of 3.0 g of 2,4-dinitrofluorobenzene (16.12 mmol, 1 eq) and 1.17 ml ethanolamine (19.34 mmol, 1.2 eq) in acetonitrile (30 ml) with 3.56 g of K2CO3 (25.79 mmol, 1.6 eq) was heated at 65° C. overnight. The reaction mixture became red. The solvent was removed under reduced pressure. The residue was diluted in 1N Na2CO3 and extracted with ethyl acetate (5×50 ml). The combined organic layer was washed with saturated NaCl (3×20 ml), dried over MgSO4 and concentrated under reduced pressure. To this orange solution was added ethanol (20 ml) and the mixture was heated at 80° C. until dissolution was complete. Distilled water (20 ml) was added and the solution was cooled to room temperature over a period of 1 hour. The yellow solid which crystallized was collected by filtration, washed with 30/70:ethanol/water and then distilled water (2×30 ml). The solid was dried by lyophilization.

1. customThe solvent was removed under reduced pressure
2. additionThe residue was diluted in 1N Na2CO3
3. extractionextracted with ethyl acetate (5×50 ml)
4. washThe combined organic layer was washed with saturated NaCl (3×20 ml)
5. dry with materialdried over MgSO4
6. concentrationconcentrated under reduced pressure
7. additionTo this orange solution was added ethanol (20 ml)
8. temperaturethe mixture was heated at 80° C. until dissolution
9. additionDistilled water (20 ml) was added
10. temperaturethe solution was cooled to room temperature over a period of 1 hour
11. customThe yellow solid which crystallized
12. filtrationwas collected by filtration
13. washwashed with 30/70
14. customThe solid was dried by lyophilization