1-(5-Chloromethylthiophen-2-yl)-cyclopent-3-ene carboxylic acid ethyl ester → 3-[5-(1-ethoxycarbonylcyclopent-3-enyl)thiophen-2-ylmethyl]-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester

HRID 481417Notes

Reaction equation

HRID 481417 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:11]2[S:12][C:13]([CH2:16]Cl)=[CH:14][CH:15]=2)[CH2:10][CH:9]=[CH:8][CH2:7]1)=[O:5])[CH3:2].[CH2:18]([O:20][C:21]([C:23]1[NH:24][C:25]([CH2:30][CH2:31][CH3:32])=[N:26][C:27]=1[CH2:28][CH3:29])=[O:22])[CH3:19]>>[CH2:18]([O:20][C:21]([C:23]1[N:24]([CH2:16][C:13]2[S:12][C:11]([C:6]3([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:10][CH:9]=[CH:8][CH2:7]3)=[CH:15][CH:14]=2)[C:25]([CH2:30][CH2:31][CH3:32])=[N:26][C:27]=1[CH2:28][CH3:29])=[O:22])[CH3:19]

Participants

3

Reactant 2

HCID 545331371-(5-Chloromethylthiophen-2-yl)-cyclopent-3-ene carboxylic acid ethyl esterHCID 178440056HCID 178440056, compound

Product 1

HCID 700844703-[5-(1-ethoxycarbonylcyclopent-3-enyl)thiophen-2-ylmethyl]-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester

Procedure

Alkylation was carried out on 1-(5-chloromethylthiophen-2-yl)cyclopent-3-ene carboxylic acid ethyl ester (5) as described in Example 1, Step 5, using 5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester (74) to obtain the title compound (73).

Sources & evidence

ORD record
ord-f99d8e7117004bf0bbc77d3fc8fd57a0
Source dataset
uspto-grants-1998_08
Patent number
US05789415

Reaction notes

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