反应详情

60.0 g (168.8 mmol) of methyl 2-chloro-4-methylsulfonyl-3-(3a,4,5,6a-tetrahydrofuro[3,2-d]isoxazol-3-yl)benzoate are dissolved in 600 ml of tetrahydrofuran/300 ml of water, and 7.34 g (183.4 mmol) of sodium hydroxide are added. After the reaction mixture has been stirred for 18 hours at room temperature, it is concentrated, brought to pH 2 with 2 N hydrochloric acid and extracted with dichloromethane. This gives 63.6 g of crude 2-chloro-4-methylsulfonyl-3-(3a,4,5,6a-tetrahydrofuro[3,2-d]isoxazol-3yl)benzoic acid as a foam.

1. additionare added
2. concentrationit is concentrated
3. extractionextracted with dichloromethane