反应详情

温度

5 °C

Benzyl chloroformate (15.5 g) was added dropwise to a stirred mixture of (2S)-2-aminoadipic acid (12 g) and sodium carbonate (39.4 g) which had been cooled to 5° C. The mixture was stirred at ambient temperature for 16 hours. The mixture was washed with diethyl ether. The aqueous phase was acidified to pH1 by the addition of dilute aqueous hydrochloric acid and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated to give (2S)-2-benzyloxycarbonylaminoadipic acid (21.6 g).

1. washThe mixture was washed with diethyl ether
2. additionThe aqueous phase was acidified to pH1 by the addition of dilute aqueous hydrochloric acid
3. extractionextracted with ethyl acetate
4. dry with materialThe organic phase was dried (MgSO4)
5. customevaporated